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KINTAI has been focusing on the production of Lappaconitine Hydrobromide for ten years. It is an alkaloid (Labaconitine) extracted from the roots of the Ranunculaceae plant Aconitum. It is a white crystalline powder extracted and isolated from the thick roots of Aconitum aconitum.
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In the past ten years, we have focused on the research and development of aconitine hydrobromide, breaking through the technical bottleneck, achieving high purity and no impurities, and ensuring the quality and efficacy of each batch of production.
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What Is Lappaconitine?
Aconitine Hydrobromide: An Effective Analgesic
After more than ten years of verification in the domestic and foreign markets, it has been proved that aconitine hydrobromide is an analgesic drug with a wide range of adaptability. Through 26 years of clinical application, it has been proved that whether it is made into tablets, water injections, powder injections, or patches, it has the effects of local anesthesia, cooling, and antipyretic, anti-inflammatory and swelling. More importantly, it has no addiction, no side effects, and is a natural plant extract that is safe.
Benefits of Aconitine Hydrobromide in Pain Management
It has special effects on pain caused by chronic diseases such as bone and joint pain in the elderly, intractable pain such as pain caused by cancer, and pain caused by inflammation. Aconitine hydrobromide is also suitable for general body pain and fever caused by the early stages of a cold.
Production Excellence
Strength in manufacturing
Direct relationship with source factories
Quality Assurance
Strict material selection
Consistent batch stability
Product Availability
Ready stock inventory
Wide range of specifications
Customer Support
Testing support
Manufacturer direct sales
Pharmaceutical-grade products
OEM and ODM supportÂ
our certifications
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As the source manufacturer of aconitine hydrobromide powder, KINTAI's aconitine hydrobromide preparation process has the following production advantages:
why choose our products
- Efficient extraction process: We use thermal reflux extraction technology, combined with alkalization and solvent extraction processes, to efficiently extract crude extracts from Aconitum root, improving extraction efficiency.
- Fine purification process: Through hydrochloric acid acidification and anhydrous sodium carbonate alkalization process, impurities can be effectively removed to obtain high-purity aconitine crude alkali, ensuring the quality and purity of the product.
- Â Impurity removal technology: The use of chromatographic alumina filtration to adsorb impurities can further purify the filtrate, reduce the impurity content, and improve the purity and quality of the product.
- Crystallization refining process: Using static crystallization and vacuum drying technology, the crystals can be fully crystallized and finely washed to obtain high-quality coarse crystals, which provides good raw material conditions for subsequent fine processing and reactions.
- Environmentally friendly and efficient: Our new process not only improves production efficiency and product quality, but also pays attention to environmental protection, reduces the emission of waste and pollutants, and is in line with the modern green production concept.
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The above process enables us to produce high-quality, high-purity aconitine hydrobromide powder, which meets our customers' needs for product quality and purity, while also improving our production efficiency and reducing production costs.
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All of Kintai's Aconitum sinomontanum Nakai roots grow on the alpine grasslands of Xinjiang above 2500 meters above sea level, pollution-free, green and organic. Every year, we purchase about 200 tons of Aconitum sinomontanum Nakai roots from Xinjiang, and produce more than 800 kg of lappaconitine with a content of more than 96%.
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Herbal Base of Aconitum sinomontanum Nakai
Aconitum sinomontanum Nakai
Roots of Aconitum sinomontanum Nakai
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Kintai mainly produces high-grade homogenin hydrobromide 98% (this product), if you need other specifications, please feel free to contact us.
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Aconitum sinomontanum Nakai is a plant of Aconitum in Ranunculaceae. Perennial herb, the root is 20 cm long, cylindrical, and 2 cm thick.It is distributed in Xinjiang, Sichuan, Guizhou, western Hubei, eastern Qinghai, southern Gansu, Shaanxi, Shanxi and Hebei. Growing in hillside grassland or forest.
The root is used for medicine to treat palpitations, stomachache, bruises, etc.a
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Aconitum sinomontanum Nakai
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LappaconitineÂ
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Product name |
Lappaconitine |
|
Extract source |
Aconitum sinomontanum Nakai |
|
Extraction Solvent |
Water/Ethyl alcohol |
|
Appearance |
White Powder |
|
Solubility |
Dissolved in water |
|
Identification |
Titration;HPLC |
|
Sulphated Ash |
NMT 0.5% |
|
Heavy metals |
NMT 20 PPM |
|
Loss On Drying |
NMT 5.0% |
|
Powder size |
80Mesh, NLT90% |
|
Assay of Lappaconitine (HPLC test, percent, Standard in House) |
Min. 98.0% |
|
Microbiological Quality (Total viable aerobic count) |
|
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- Bacteria, CFU/g, not more than |
NMT 103 |
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- Moulds and yeasts, CFU/g, not more than |
NMT 102 |
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- E.coli, Salmonella, S. aureus, CFU/g |
Absence |
|
Storage |
2-8 ℃ |
|
Shelf life |
three years |
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Health Benefits
According to the latest pharmacological experiments, Lappaconitine hydrobromide has the following effects on health:
Analgesic effect, without obvious toxicity and addiction;
Anti inflammatory effect, lappaconitine has anti acute and chronic inflammatory effects;
Anti arrhythmic effect, lappaconitine  can significantly improve myocardial ischemic arrhythmia, thereby reducing the incidence of arrhythmia;
Cooling and eliminating fever: It has a significant antipyretic effect on various types of fever. It has been clinically proven that the antipyretic effect is better than hydropyrine, and its cooling effect is equal to aspirin and other western medicines.
Application
It is applicable to gastrointestinal ulcer, gastritis, hepatitis, cholecystitis, rheumatism, sciatica, toothache, postoperative pain, etc.
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The hydrobromide is commonly used in clinical practice, and there are various preparations and specifications. Their administration methods, routes, absorption speed, and stability are different, and each has its own characteristics. The preparations of different manufacturers may have different drug effects and adverse reactions due to different production processes. How to choose please consult your doctor.
1) Houginine hydrobromide tablets: 5 mg; 10 mg.
2) Hovenine hydrobromide for injection: 4 mg; 8 mg.
3) Urine hydrobromide injection: 4mg/2ml; 8mg/2ml.
4) Urumine hydrobromide glucose injection: 250 ml (4 mg urine hydrobromide, 12.5 grams of 5) glucose); 500 ml (8 mg urine hydrobromide, 25 grams of glucose)
6) Gao Ujiasu patch: 12 mg.
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(1) The analgesic effect of lappaconitine is lasting, because the anesthetic isomer of aconitum has strong anesthetic effect from deep layer to shallow layer.
(2) It is clinically proved that the local anesthetic effect is equivalent to cocaine; The effect of nerve conduction block is 5.25 times that of cocaine and 13 times that of procaine; The effect of infiltration anesthesia is far stronger than that of procaine and cocaine.
(3) The lappaconitine has high safety, no addiction, mutagenic and carcinogenic effects, no accumulation, stimulation, allergic reaction and toxic effects on the immune system. The clinical application proved that there was no case of poisoning within the prescribed usage and dosage.
(4) It has significant antipyretic effect on all kinds of fever. It is clinically proved that antipyretic effect is better than aminopyrine, and its cooling effect is equal to aspirin and other western medicines.
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If you want to purchase high-quality Lappaconitine hydrobromide, please feel free to contact us at or feedback on the next page.
http://www.kintai-bio.com/